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Symptom Burden and Recovery in the First Year After Allogeneic Hematopoietic Stem Cell Transplantation
Karolinska institutet; Karolinska universitetssjukhuset.
Karolinska institutet; Sophiahemmet högskola.
Marie Cederschiöld University, Department of Health Care Sciences, Palliative Research Centre, PRC. Karolinska institutet.ORCID iD: 0000-0002-0197-9121
Karolinska institutet; Karolinska universitetssjukhuset.
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2023 (English)In: Cancer Nursing, ISSN 0162-220X, E-ISSN 1538-9804, Vol. 46, no 1, p. 77-85Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Patients are affected by various symptoms after allogeneic hematopoietic stem cell transplantation (allo-HSCT) that can affect recovery. Research has mainly focused on symptom occurrence; thus, little is known about patients' overall symptom burden.

OBJECTIVE: The aim of this study was to examine patient-reported symptom burden in the first year after allo-HSCT and whether a high symptom burden 4 months after allo-HSCT predicts recovery, that is, general health and sick leave, 1 year after transplantation.

METHODS: Allo-HSCT patients aged 18 to 65 years were included (n = 189). Questionnaire data were collected on admission to the allo-HSCT unit, as well as 4 and 7 months and 1 year after allo-HSCT. Logistic regression evaluated relationships between demographic characteristics, chronic graft-versus-host disease, physical activity, and a high symptom burden.

RESULTS: Tiredness, susceptibility to infection, disinterest in sex, and physical weakness remained the most frequent symptoms, while distressing symptoms varied during the first year after allo-HSCT.Poor general health 1 year after allo-HSCT was associated with older age, low physical activity, and a high symptom burden 4 months after allo-HSCT. Full-time sick leave 1 year after allo-HSCT was associated with chronic graft-versus-host disease, low physical activity, and a high symptom burden 4 months after transplantation.

CONCLUSIONS: Experiencing a high symptom burden 4 months after allo-HSCT can affect recovery 1 year after transplantation. Furthermore, low physical activity 4 months after allo-HSCT can predict both general health and sick leave 1 year after transplantation.

IMPLICATIONS FOR PRACTICE: Repeated symptom assessment, including experienced distress, is central for reducing overall symptom burden and supporting recovery after allo-HSCT.

Place, publisher, year, edition, pages
2023. Vol. 46, no 1, p. 77-85
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Nursing
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URN: urn:nbn:se:esh:diva-9453DOI: 10.1097/NCC.0000000000001077ISI: 000892426400015PubMedID: 35283470OAI: oai:DiVA.org:esh-9453DiVA, id: diva2:1652480
Available from: 2022-04-19 Created: 2022-04-19 Last updated: 2023-01-11Bibliographically approved

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