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Dosage effects of riluzole in Huntington's disease: a multicenter placebo-controlled study.
2003 (English)In: Neurology, ISSN 0028-3878, E-ISSN 1526-632X, Vol. 61, no 11, p. 1551-6Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Riluzole retards striatal glutamate release and pathologic consequences in neurotoxic animal models of Huntington's disease (HD).

OBJECTIVE: To determine the dosage-related impact of riluzole on chorea in HD.

METHODS: An 8-week double-blind dose-ranging multicenter study of riluzole was conducted in 63 subjects (32 women, 31 men) with HD who were randomized to receive placebo, riluzole 100 mg/day, or riluzole 200 mg/day. The prespecified outcome measure was change in the total maximal chorea score of the Unified Huntington's Disease Rating Scale (UHDRS).

RESULTS: Fifty-six (89%) subjects completed the study. A reduction (p < 0.01) in chorea at 8 weeks was found using a linear trend test with dose. Comparing the groups individually, the reduction in chorea for the riluzole 200-mg/day group (-2.2 +/- 3.3) was different (p = 0.01) from placebo (+0.7 +/- 3.4), but the riluzole 100-mg/day group (-0.2 +/- 2.9) was not. Riluzole did not improve other motor, cognitive, behavioral, or functional components of the UHDRS. Alanine aminotransferase was elevated in a dosage-dependent fashion (p = 0.01).

CONCLUSIONS: Over 8 weeks of treatment, riluzole 200 mg/day ameliorated chorea intensity in HD without improving functional capacity or other clinical features of illness. Riluzole 200 mg/day was attended by reversible liver transaminase abnormalities that would require monitoring in long-term studies.

Place, publisher, year, edition, pages
2003. Vol. 61, no 11, p. 1551-6
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Nursing
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URN: urn:nbn:se:esh:diva-7500PubMedID: 14663041OAI: oai:DiVA.org:esh-7500DiVA, id: diva2:1317245
Available from: 2019-05-22 Created: 2019-05-22 Last updated: 2019-05-22Bibliographically approved

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